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KMID : 0545120110210101097
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Journal of Microbiology and Biotechnology
2011 Volume.21 No. 10 p.1097 ~ p.1100
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In Silico Study of the Ion Channel Formed by Tolaasin I Produced by Pseudomonas tolaasii
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Jo Geun-Hyeong
Hwang Do-seok
Lee Sun-Hee
Woo Yoon-kyung
Hyun Ji-ye
Yong Yeon-Joong
Kang Kyung-Rai
Kim Dong-Woon
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Abstract
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A toxin produced by Pseudomonas tolaasii, tolaasin, causes brown blotch disease in mushrooms. Tolaasin forms pores on the cellular membrane and destroys cell structure. Inhibiting the ability of tolaasin to form ion channels may be an effective method to protect against attack by tolaasin. However, it is first necessary to elucidate the three-dimensional structure of the ion channels formed by tolaasin. In this study, the structure of the tolaasin ion channel was determined in silico based on data obtained from nuclear magnetic resonance experiments.
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KEYWORD
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tolaasin ion channel, Pseudomonas tolaasi
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